Kufunika kwa achire
COVID-19 imayamba chifukwa cha kachilombo ka SARS-CoV-2 pathogen, yomwe imalowa ndikulowa m'ma cell omwe amalandila kudzera mu protein yake ya spike.Pakadali pano, pali milandu yopitilira 138.3 miliyoni padziko lonse lapansi, ndipo anthu omwalira akuyandikira mamiliyoni atatu.
Ngakhale katemera wavomerezedwa kuti agwiritsidwe ntchito mwadzidzidzi, mphamvu yake yolimbana ndi mitundu ina yatsopanoyi yakayikira.Kuphatikiza apo, kulandira katemera wa anthu osachepera 70% m'maiko onse padziko lapansi kuyenera kutenga nthawi yayitali, poganizira momwe katemera akuyendera, kuchepa kwa katemera, komanso zovuta zogwirira ntchito.
Dziko lidzafunabe mankhwala othandiza komanso otetezeka, choncho, kuti alowerere ku matenda aakulu omwe amayamba chifukwa cha kachilomboka.Ndemanga yapano ikuyang'ana pamunthu payekha komanso synergistic ntchito ya curcumin ndi nanostructures motsutsana ndi kachilomboka.

Kufunika kwa achire
COVID-19 imayamba chifukwa cha kachilombo ka SARS-CoV-2 pathogen, yomwe imalowa ndikulowa m'ma cell omwe amalandila kudzera mu protein yake ya spike.Pakadali pano, pali milandu yopitilira 138.3 miliyoni padziko lonse lapansi, ndipo anthu omwalira akuyandikira mamiliyoni atatu.
Ngakhale katemera wavomerezedwa kuti agwiritsidwe ntchito mwadzidzidzi, mphamvu yake yolimbana ndi mitundu ina yatsopanoyi yakayikira.Kuphatikiza apo, kulandira katemera wa anthu osachepera 70% m'maiko onse padziko lapansi kuyenera kutenga nthawi yayitali, poganizira momwe katemera akuyendera, kuchepa kwa katemera, komanso zovuta zogwirira ntchito.
Dziko lidzafunabe mankhwala othandiza komanso otetezeka, choncho, kuti alowerere ku matenda aakulu omwe amayamba chifukwa cha kachilomboka.Ndemanga yapano ikuyang'ana pamunthu payekha komanso synergistic ntchito ya curcumin ndi nanostructures motsutsana ndi kachilomboka.

Curcumin
Curcumin ndi gulu la polyphenolic lomwe liri kutali ndi rhizome ya chomera cha turmeric, Curcuma longa.Zimapanga curcuminoid yaikulu mu chomerachi, pa 77% ya chiwerengero chonse, pamene curcumin II yaying'ono imapanga 17%, ndipo curcumin III imakhala ndi 3%.
Curcumin yadziwika ndikuphunziridwa bwino, ngati molekyulu yachilengedwe yokhala ndi mankhwala.Kulekerera kwake ndi chitetezo chalembedwa bwino, ndi mlingo waukulu wa 12 g / tsiku.
Kugwiritsa ntchito kwake kwafotokozedwa ngati anti-yotupa, anticancer, ndi antioxidant, komanso antiviral.Curcumin akuti ndi molekyulu yomwe imatha kuchiritsa edema yam'mapapo ndi njira zina zovulaza zomwe zimatsogolera kumapapu fibrosis kutsatira COVID-19.

Curcumin imalepheretsa ma enzymes a virus
Izi zimaganiziridwa kuti ndi chifukwa cha kuthekera kwake kuletsa kachilombo komweko, komanso kuwongolera njira zotupa.Imawongolera kulembedwa kwa ma virus ndi kuwongolera, kumangiriza ndi mphamvu yayikulu ku enzyme ya virus main protease (Mpro) yomwe ndiyofunikira pakubwereza komanso kuletsa kulumikizidwa kwa ma virus ndikulowa mu cell yolandirira.Zitha kusokonezanso ma virus.
Zolinga zake zolimbana ndi ma virus ndi kachilombo ka hepatitis C, kachilombo ka HIV, Epstein-Barr virus ndi fuluwenza A.Zanenedwa kuti zimalepheretsa 3C-like protease (3CLpro) bwino kwambiri kuposa zinthu zina zachilengedwe, kuphatikiza quercetin, kapena mankhwala monga chloroquine ndi hydroxychloroquine.
Izi zitha kulola kuchepetsa kuchuluka kwa ma virus mkati mwa cell yamunthu mwachangu kwambiri kuposa mankhwala ena osaletsa, motero kuletsa kupitilira kwa matenda kupita ku acute Respiratory Distress Syndrome (ARDS).
Imalepheretsanso puloteni ya papain (PLpro) yokhala ndi 50% inhibitory concentration (IC50) ya 5.7 µM yomwe imaposa quercetin ndi zinthu zina zachilengedwe.

Curcumin imalepheretsa ma cell receptors
Kachilomboka kamalowa ku cell host target cell receptor, angiotensin-converting enzyme 2 (ACE2).Kafukufuku wama Model awonetsa kuti curcumin imalepheretsa kuyanjana kwa virus-receptor m'njira ziwiri, poletsa mapuloteni onse a spike ndi ACE2 receptor.
Komabe, curcumin imakhala ndi bioavailability yochepa, chifukwa sichisungunuka bwino m'madzi ndipo imakhala yosasunthika m'madzi amadzimadzi, makamaka pa pH yapamwamba.Ikaperekedwa pakamwa, imalowa m'matumbo ndi chiwindi mwachangu.Cholepheretsa ichi chikhoza kugonjetsedwa pogwiritsa ntchito nanosystems.
Zonyamulira zambiri za nanostructured zitha kugwiritsidwa ntchito pazifukwa izi, monga nanoemulsions, microemulsions, nanogels, micelles, nanoparticles ndi liposomes.Zonyamulira zotere zimalepheretsa kuwonongeka kwa metabolic kwa curcumin, kumawonjezera kusungunuka kwake ndikuthandizira kudutsa muzinthu zachilengedwe.
Zogulitsa zitatu kapena zingapo za curcumin zochokera ku nanostructure zilipo kale pamalonda, koma kafukufuku wochepa wawunika momwe zimagwirira ntchito motsutsana ndi COVID-19 mu vivo.Izi zikuwonetsa kuthekera kwa mapangidwewo kuti asinthe momwe chitetezo cha mthupi chimayankhira ndikuchepetsa zizindikiro za matendawa, mwinanso kufulumira kuchira.